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Jean-Lucien Rouleau Selected Research

omapatrilat

10/2005Vasopeptidase inhibition peri- and post-MI in Zucker insulin resistant rats: effect on MI size, arrhythmias, remodeling, function and fetal gene expression.
3/2005Effects of the vasopeptidase inhibitor omapatrilat on peri- and postmyocardial infarction in Zucker lean rats.
7/2003Effects of pre-, peri-, and postmyocardial infarction treatment with omapatrilat in rats: survival, arrhythmias, ventricular function, and remodeling.
8/2002Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE).
1/2002Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression.

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Jean-Lucien Rouleau Research Topics

Disease

41Heart Failure
01/2022 - 04/2002
23Myocardial Infarction
11/2021 - 01/2002
9Left Ventricular Dysfunction
09/2012 - 08/2002
7Hypertension (High Blood Pressure)
08/2013 - 04/2002
6Stroke (Strokes)
01/2020 - 04/2003
6Coronary Artery Disease (Coronary Atherosclerosis)
08/2013 - 11/2002
5Heart Arrest (Cardiac Arrest)
01/2022 - 09/2004
4Diabetic Nephropathies (Diabetic Nephropathy)
07/2005 - 04/2003
4Infarction (Infarctions)
04/2005 - 07/2003
3Diabetes Mellitus
01/2019 - 07/2004
3Inflammation (Inflammations)
12/2013 - 03/2007
3Insulin Resistance
03/2007 - 03/2005
3Ischemia
06/2006 - 11/2002
3Cardiomegaly (Heart Hypertrophy)
11/2005 - 07/2002
2Sudden Death
01/2022 - 11/2020
2Cardiac Arrhythmias (Arrythmia)
01/2022 - 07/2003
2Disease Progression
01/2017 - 08/2013
2Fibrosis (Cirrhosis)
12/2013 - 07/2002
2Atrial Fibrillation
09/2012 - 10/2006
2Acute Coronary Syndrome
11/2005 - 09/2004
2Cardiovascular Diseases (Cardiovascular Disease)
11/2004 - 09/2004
2Type 2 Diabetes Mellitus (MODY)
08/2004 - 04/2003
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
07/2003 - 07/2002
1Shock
01/2022
1ST Elevation Myocardial Infarction
01/2021
1Frailty
01/2020
1Malnutrition (Nutritional Deficiencies)
01/2019
1Glucose Intolerance
10/2018
1Tachycardia (Tachyarrhythmias)
01/2017
1Hypokalemia
01/2015
1Hyperkalemia
01/2015
1Pulmonary Edema
08/2013
1Edema (Dropsy)
08/2013
1Chest Pain (Chest Pains)
08/2013
1Cardiomyopathies (Cardiomyopathy)
08/2013
1Ventricular Fibrillation
12/2008
1Ventricular Tachycardia
12/2008
1Necrosis
04/2007
1Sleep Apnea Syndromes (Sleep Apnea)
10/2005
1Right Ventricular Hypertrophy
03/2005
1Albuminuria
11/2004

Drug/Important Bio-Agent (IBA)

10Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
11/2021 - 01/2002
8Valsartan (Vals)FDA Link
11/2021 - 11/2003
8Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
03/2007 - 01/2002
6Mineralocorticoid Receptor AntagonistsIBA
11/2021 - 01/2006
5candesartanIBA
01/2021 - 10/2003
5Spironolactone (Aldactone)FDA LinkGeneric
01/2020 - 01/2006
5Insulin (Novolin)FDA Link
01/2019 - 09/2004
5CreatinineIBA
01/2015 - 04/2003
5Vasopeptidase InhibitorsIBA
10/2005 - 01/2002
5omapatrilatIBA
10/2005 - 01/2002
4sacubitril and valsartan sodium hydrate drug combinationIBA
01/2022 - 11/2020
4EnalaprilFDA LinkGeneric
01/2022 - 08/2002
4Neprilysin (Neutral Endopeptidase)IBA
11/2021 - 01/2002
4Biomarkers (Surrogate Marker)IBA
01/2019 - 02/2003
4Angiotensin Receptor AntagonistsIBA
04/2009 - 04/2003
4IrbesartanFDA LinkGeneric
07/2005 - 04/2003
4Captopril (Capoten)FDA LinkGeneric
08/2004 - 01/2002
3PotassiumIBA
11/2020 - 01/2015
3Quinapril (Accupril)FDA LinkGeneric
06/2006 - 11/2002
3Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
11/2005 - 09/2004
3Proteins (Proteins, Gene)FDA Link
07/2005 - 07/2002
2Ramipril (Altace)FDA LinkGeneric
01/2022 - 11/2021
2Glucose (Dextrose)FDA LinkGeneric
10/2018 - 03/2007
2DiureticsIBA
01/2017 - 05/2002
2Metoprolol (Toprol-XL)FDA LinkGeneric
01/2017 - 10/2003
2Vasodilator Agents (Vasodilators)IBA
01/2017 - 05/2002
2Amlodipine (Norvasc)FDA LinkGeneric
08/2013 - 04/2003
2CytokinesIBA
04/2007 - 01/2002
2Natriuretic PeptidesIBA
03/2007 - 04/2003
2Losartan (Cozaar)FDA LinkGeneric
11/2005 - 04/2005
2Creatine Kinase (Creatine Phosphokinase)IBA
09/2004 - 12/2002
2Messenger RNA (mRNA)IBA
07/2002 - 01/2002
1Angiotensin Receptors (Angiotensin II Receptor)IBA
11/2021
1sacubitrilIBA
11/2021
1Eplerenone (Inspra)FDA LinkGeneric
10/2018
1MineralocorticoidsIBA
10/2018
1flosequinanIBA
01/2017
1Bisoprolol (Concor)FDA LinkGeneric
01/2017
1Pharmaceutical PreparationsIBA
01/2017
1Carvedilol (Coreg)FDA LinkGeneric
01/2017
1Brain Natriuretic Peptide (Natrecor)FDA Link
07/2008
1C-Reactive ProteinIBA
03/2007
1pro-brain natriuretic peptide (1-76)IBA
03/2007
1Indicators and Reagents (Reagents)IBA
10/2006
1LipidsIBA
11/2005
1ORALIT (ORS)IBA
10/2005
1AlbuminsIBA
11/2004
1Serum AlbuminIBA
11/2004
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
09/2004

Therapy/Procedure

17Therapeutics
11/2021 - 05/2002
2Percutaneous Coronary Intervention
01/2021 - 08/2006
2Coronary Artery Bypass (Coronary Artery Bypass Surgery)
04/2011 - 11/2002
1Cardiac Resynchronization Therapy
01/2022
1Defibrillators (Defibrillator)
01/2022
1Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
01/2022
1Polypharmacy
11/2021
1Continuous Positive Airway Pressure
10/2005
1Surgical Amputation (Amputations)
11/2004
1Resuscitation
09/2004